Photon-Efficient Computational 3D and Reflectivity Imaging with Single-Photon Detectors

Capturing depth and reflectivity images at low light levels from active illumination of a scene has wide-ranging applications. Conventionally, even with single-photon detectors, hundreds of photon detections are needed at each pixel to mitigate Poisson noise. We develop a robust method for estimating depth and reflectivity using on the order of 1 detected photon per pixel averaged over the scene. Our computational imager combines physically accurate single-photon counting statistics with exploitation of the spatial correlations present in real-world reflectivity and 3D structure. Experiments conducted in the presence of strong background light demonstrate that our computational imager is able to accurately recover scene depth and reflectivity, while traditional maximum-likelihood based imaging methods lead to estimates that are highly noisy. Our framework increases photon efficiency 100-fold over traditional processing and also improves, somewhat, upon first-photon imaging under a total acquisition time constraint in raster-scanned operation. Thus our new imager will be useful for rapid, low-power, and noise-tolerant active optical imaging, and its fixed dwell time will facilitate parallelization through use of a detector array.Comment: 11 pages, 8 figure

Challenges and learning opportunities involved in the professional development of mathematics teachers within the government sector

As Professional Development Teachers (PDTs), we have been working in the government sector for the last several years to improve the profile of Mathematics teachers within the sector. Our experience of the Professional Development of teachers suggests that working in the government sector is not an easy task. However, neither is it an impossible one. The government’s system faces varied challenges in tackling the professional development needs of teachers. The most important one is the capacity of the professional staff to undertake this mammoth job. Secondly, there is a strong need to change the perceptions of policymakers to consider the professional development in the continuum rather than one singular event. This requires a strong support structure to conduct the Professional Development activities in an ongoing manner. Through our paper, we would like to outline our experiences to present how we have become engaged in the processes of developing Mathematics teachers within the government sector and what are the challenges that we are facing in continuing our efforts to take these efforts further. It is also very important to mention that the Mathematics Association of Pakistan (MAP) has remained very responsive to our ongoing professional needs to carry forward our responsibilities within the government sector

Diffuse Imaging: Creating Optical Images With Unfocused Time-Resolved Illumination and Sensing

Conventional imaging uses steady-state illumination and light sensing with focusing optics; variations of the light field with time are not exploited. We develop a signal processing framework for estimating the reflectance of a Lambertian planar surface in a known position using omnidirectional, time-varying illumination and unfocused, time-resolved sensing in place of traditional optical elements such as lenses and mirrors. Our model associates time sampling of the intensity of light incident at each sensor with a linear functional of . The discrete-time samples are processed to obtain -regularized estimates of . Improving on previous work, using nonimpulsive, bandlimited light sources instead of impulsive illumination significantly improves signal-to-noise ratio (SNR) and reconstruction quality. Our simulations suggest that practical diffuse imaging applications may be realized with commercially-available temporal light intensity modulators and sensors used in standard optical communication systems.National Science Foundation (U.S.). (Grant number 0643836)United States. Defense Advanced Research Projects Agency. Information in a Photon Program (United States. Army Research Office)(Award number W911-NF-10-1-0404)Texas Instruments Leadership University Consortium Progra

Hajdu cheney syndrome due to NOTCH2 defect - First case report from Pakistan and review of literature

Introduction and importance: Hajdu Cheney Syndrome (HCS) is a rare skeletal disease characterized by severe, progressive focal bone loss with osteoporosis, variable craniofacial, vertebral anomalies and distinctive facial features. It is inherited as an autosomal dominant disease although sporadic cases have been described in literature. Identifying these cases in clinical practice is important for proper diagnosis and management.Case presentation: We report a case of a 36-year-old male patient presented at metabolic bone disease clinic at the Aga Khan University Hospital with history of multiple fragility fractures and juvenile osteoporosis since childhood. DNA sequence analysis of the NOTCH2 coding sequence revealed a pathogenic variant in NOTCH 2, Exon 34, c.6426_6427insTT (p.Glu2143Leufs*5), consistent with a NOTCH2 related conditions including HCS.Clinical discussion: The multitude of presentations associated with HCS are linked to the NOTCH2 gene, as Notch signaling is one of the core signaling pathways that control embryonic development. Hence, mutations in the Notch signaling pathway cause developmental phenotypes that affect various organs including the liver, skeleton, heart, eye, face, kidney, and vasculature.Conclusion: To the best of our knowledge, nucleotide mutations of c.6933delT, c.6854delA, c.6787C.T, and c.6424-6427delTCTG were all determined to be novel, with c.6428T \u3e C being the most common mutation found in literature. The c.6426_6427insTT mutation our patient was found to have via gene sequencing too appears to be a novel mutation, which has not previously been reported in literature

Perspective on newborn screening (NBS): Evidence sharing on conditions to be included in NBS in Pakistan

Newborn screening aims at detecting treatable disorders early so that the treatment can be initiated to prevent mortality and morbidity. Such programmes are well established in most developed countries, and all newborns are screened for selected metabolic, endocrine and other disorders based on disease epidemiology, testing and treatment availability, efficiency and cost-effectiveness. Even in developing countries, such screening programmes are initiated using heel prick capillary blood collected on filter paper. The current narrative review was planned to provide a perspective with evidence in favour of starting newborn screening for different disorders. The programme project should be initiated nationwide, taking one disorder, congenital hypothyroidism, as the prototype and a newborn screening panel can then be extended to include other disorders. A task force should be set up to recommend disorders to be included in the panel, develop the national plan policies, and define procedures to strengthen the testing

Diffuse imaging: Creating optical images with unfocused time-resolved illumination and sensing

Abstract-Conventional imaging uses steady-state illumination and light sensing with focusing optics; variations of the light field with time are not exploited. We develop a signal processing framework for estimating the reflectance f of a Lambertian planar surface in a known position using omnidirectional, timevarying illumination and unfocused, time-resolved sensing in place of traditional optical elements such as lenses and mirrors. Our model associates time sampling of the intensity of light incident at each sensor with a linear functional of f . The discretetime samples are processed to obtain 2 -regularized estimates of f . Improving on previous work, using non-impulsive, bandlimited light sources instead of impulsive illumination significantly improves signal-to-noise ratio (SNR) and reconstruction quality. Our simulations suggest that practical diffuse imaging applications may be realized with commercially-available temporal light intensity modulators and sensors used in standard optical communication systems

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Mortality and pulmonary complications in patients undergoing surgery with perioperative sars-cov-2 infection: An international cohort study

Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (740%) had emergency surgery and 280 (248%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (261%) patients. 30-day mortality was 238% (268 of 1128). Pulmonary complications occurred in 577 (512%) of 1128 patients; 30-day mortality in these patients was 380% (219 of 577), accounting for 817% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 175 [95% CI 128-240], p<00001), age 70 years or older versus younger than 70 years (230 [165-322], p<00001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (235 [157-353], p<00001), malignant versus benign or obstetric diagnosis (155 [101-239], p=0046), emergency versus elective surgery (167 [106-263], p=0026), and major versus minor surgery (152 [101-231], p=0047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research